does l carnitine cause insomnia

View abstract. 2006;72(3):231-237. Schlenzig JS, Charpentier C, Rabier D, et al. L-Carnosine (Fig. View abstract. View abstract. Kidney Blood Press Res. Both humans and mice naturally produce acetyl L-carnitine under normal conditions, but studies have shown that some depression-prone animals are deficient in acetyl L-carnitine. Saturated fat 10 and added sugars are linked to a myriad of health problems such as heart disease, type 2 diabetes, and obesity. Sports Med 1996;22:109-32. (pre-publication author's copy, via correspondence) 2002;1-14. Written by Cerner Multum. Bull.Exp.Biol.Med. Tempesta E, Troncon R, Janiri L, et al. Vacha, G. M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M. L-carnitine addition to dialysis fluid. World J Gastroenterol. J.HainanMed.College 2011;17(3):347-349. Tempesta E, Casella L, Pirrongelli C, et al. J Nephrol. View abstract. Zhonghua Nan.Ke.Xue. L-Carnitine Uses, Side Effects & Warnings - Drugs.com View abstract. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 2020;37:9-23. These include: stomach cramps nausea vomiting diarrhea Some. Common L-carnitine side effects include stomach pain, nausea, vomiting and diarrhea. 2013 May;19(5):576-85. View abstract. Graziano F, Bisonni R, Catalano V, et al. Eur.Heart J 2007;28(5):608-612. Mitwalli A, Wakeel J Alam A Tarif N Abu-Afsha A. L-carnitine: a way to decrease cellular toxicity of ifosfamide? 2010;78(2):191-194. Jones, S., Reed, C. A., Vijay, S., Walter, J. H., and Morris, A. Memeo A., Loiero M. Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. These symptoms are not considered to be severe side effects. The protective effect of carnitine in human diphtheric myocarditis. Lancet 2 (1980): 763-4, 5. Am Heart J 2000;139:S120-3. J Clin Rheumatol. View abstract. Boehm G, Stahl B. Oligosaccharides from milk. Sarris, J., Kean, J., Schweitzer, I., and Lake, J. Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence. Do not take extra medicine to make up the missed dose. View abstract. Angiology 1989;40(10):857-862. 2010;21(7):580-588. However, one analysis of nine studies mostly in obese individuals or older adults found that people lost an average of 2.9 pounds (1.3 kg) more weight while taking L-carnitine (29). (Tokyo) 2001;47(6):378-384. 2013 Jun;19(2):165-72. This review describes the mechanism of action, metabolism and pharmacokinetics of l-carnitine. Drugs Exp Clin Res 1991;17:225-35. View abstract. 2011;42(3):217-225. View abstract. Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. More research is needed on long-term benefits for healthy individuals. Lu, S. M., Li, X., Zhang, H. B., Hu, J. M., Yan, J. H., Liu, J. L., and Chen, Z. J. Pediatr.Hematol.Oncol. Low levels of L-carnitine have been found to be associated with diabetic complications. Inflammation contributes to many medical conditions, including . Harper, P., Elwin, C. E., and Cederblad, G. Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy subjects. J Androl 2004;25(5):761-770. Lee, M. S., Lee, H. J., Lee, H. S., and Kim, Y. L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes. Cochrane.Database.Syst.Rev. Morgante, G., Scolaro, V., Tosti, C., Di, Sabatino A., Piomboni, P., and De, Leo, V. [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. This is not a complete list of side effects and others may occur. Naito J, Ohashi H, Ohno M, et al. View abstract. Desbree, A., Houdon, L., Touati, G., Djemili, S., Choker, G., and Flodrops, H. [EBV infection revealing a long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency in a 3-year-old boy]. Bianchi, G., Vitali, G., Caraceni, A., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., and Gianni, L. Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine. Berthillier G, Eichenberger D, Carrier HN, et al. Clin Exp.Rheumatol. Malaguarnera, M., Pistone, G., Astuto, M., Vecchio, I., Raffaele, R., Lo, Giudice E., and Rampello, L. Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. Rahbar, A. R., Shakerhosseini, R., Saadat, N., Taleban, F., Pordal, A., and Gollestan, B. Nutr J 2012;11:52. View abstract. View abstract. Riccioni, C., Sarcinella, R., Izzo, A., Palermo, G., Liguori, M., Caliumi, C., Carloni, E., Paolucci, A. M., D'andrea, P., and Pompili, S. Rehabilitative treatment in peripheral artery disease: protocol application and follow-up. Horvath, G. A., Davidson, A. G., Stockler-Ipsiroglu, S. G., Lillquist, Y. P., Waters, P. J., Olpin, S., Andresen, B. S., Palaty, J., Nelson, J., and Vallance, H. Newborn screening for MCAD deficiency: experience of the first three years in British Columbia, Canada. What's L-Carnitine, and Does It Live Up to the Hype? - Greatist Although dosage varies from study to study, here is an overview of the use and dose for each form: Up to 2,000 mg (2 grams) per day seems safe and effective in the long term. Curr.Opin.Pediatr. View abstract. Drugs Exp Clin Res 1995;21:187-98. Clin Ter. 2016;63(10):885-95. Fortin, G., Yurchenko, K., Collette, C., Rubio, M., Villani, A. C., Bitton, A., Sarfati, M., and Franchimont, D. L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. 2010;58(5):551-565. Cao, Y., Wang, Y. X., Liu, C. J., Wang, L. X., Han, Z. W., and Wang, C. B. Gonzalez-Ortiz, M., Hernandez-Gonzalez, S. O., Hernandez-Salazar, E., and Martinez-Abundis, E. Effect of oral L-carnitine administration on insulin sensitivity and lipid profile in type 2 diabetes mellitus patients. Cochrane.Database.Syst.Rev. J Am Soc Nephrol 2002;13:708-14.. View abstract. A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia. View abstract. Xue, Y. Lee, P. J., Harrison, E. L., Jones, M. G., Jones, S., Leonard, J. V., and Chalmers, R. A. L-carnitine and exercise tolerance in medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency: a pilot study. High levels of TMAO are linked to an increased risk of atherosclerosis a disease which clogs your arteries (59, 60). J Urol. Moretti S, Alesse E, Di Marzio L, et al. Liammongkolkul, S., Kuptanon, C., Wasant, P., Vatanavicharn, N., Sawangareetrakul, P., Keeratichamroen, S., Cairns, J. R. K., Srisomsap, C., and Svasti, J. View abstract. View abstract. Dal Negro R, Pomari G, Zoccatelli O, and et al. 1990;34(6):501-505. Zhang JJ, Wu ZB, Cai YJ, Ke B, Huang YJ, Qiu CP, Yang YB, Shi LY, Qin J. L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study. View abstract. Derosa, G., Maffioli, P., Ferrari, I., D'Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients. Palazzuoli, V., Mondillo, S., Faglia, S., D'Aprile, N., Camporeale, A., and Gennari, C. [The evaluation of the antiarrhythmic activity of L-carnitine and propafenone in ischemic cardiopathy]. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. Warfarin is used to slow blood clotting. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. [Ref], There have been reports from clinical trials of significant increases in platelet aggregation associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to hemodialysis patients. 2007;178(4 Pt 1):1398-1403. Energy Drinks | Healthy Schools | CDC View abstract. You can get small amounts of L-carnitine from your diet by eating meat and fish (4, 5). Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L., and Motta, M. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. Hurot JM, Cucherat M, Haugh M, Fouque D. Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review. Mintz M. Carnitine in human immunodeficiency virus type 1 infection/acquired immune deficiency syndrome. Invest Clin 2007;48(2):243-248. Adverse Effects / Side Effects / Safety of CoQ10 Weschler A, Aviram M, Levin M, Better OS, Brook JG "High dose of L-carnitine increases platelet aggregation and plasma triglyceride levels in uremic patients on hemodialysis." 2013;8(1):e53707. L-carnitine and Vitamin B Complex for the Treatment of Pegasparaginase-induced Hyperbilirubinemia. View abstract. Thom H, Carter PE, Cole GF, et al. Rathod, R., Baig, M. S., Khandelwal, P. N., Kulkarni, S. G., Gade, P. R., and Siddiqui, S. Results of a single blind, randomized, placebo-controlled clinical trial to study the effect of intravenous L-carnitine supplementation on health-related quality of life in Indian patients on maintenance hemodialysis. View abstract. 2009;79(3):131-141. Cardiovasc.Drugs Ther 2007;21(6):445-448. Life Sci 1996;59:1579-99. View abstract. Indian Pediatr 1992;29:1501-5. View abstract. Freeman JM, Vining EPG, Cost S, Singhi P. Does carnitine administration improve the symptoms attributed to anticonvulsant medications? Hypertension 2009;54(3):567-574. Rockstar zero carb packs a powerful boost but has zero sugar and just 10 carbs per serving. View abstract. View abstract. El Sharkwy IA, Abd El Aziz WM. 2012;7(11):1836-1842. A pilot study. Online ahead of print. Nutrients 2018;10(2). Malone, M. A., Schocken, D. D., Hanna, S. K., Liang, X., and Malone, J. I. Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitine. In an eight-week study in 38 women who exercised four times per week, there was no difference in weight loss between those who took L-carnitine and those who didnt (24). View abstract. Am J Clin Nutr 2007;86:1738-44. Marconi C, Sassi G, Carpinelli A, Cerretelli P. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. L-Carnitine in the evening + sleep lost side effect - Bodybuilding.com Tarighat, Esfanjani A., Mahdavi, R., Ebrahimi, Mameghani M., Talebi, M., Nikniaz, Z., and Safaiyan, A. Donnelly, C. T., Hameed, A. 2007;41(3):224-230. Urology 2004;63:641-6. L-Carnosine - Nootropics Expert The dose of your acenocoumarol might need to be changed. View abstract. Eur.J Haematol. J Perinatol. View abstract. In addition to the L-carnitine produced in your body, you can also obtain small amounts by eating animal products like meat or fish (5). Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performance. J Vasc.Surg. Effects of l-carnitine supplementation on weight loss and body - PubMed View abstract. View abstract. Med.Sci Monit. 2010;20(11):693-700. Eur J Obstet Gynecol Reprod Biol 2014;180:148-52. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. El Beshlawy, A., Abd, El Raouf, Mostafa, F., Talaat, M., Isma'eel, H., Aoun, E., Hoffbrand, A. V., and Taher, A. Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment? View abstract. 2010;62(3):213-218. Cell Biol.Int. l-Carnitine causes insomnia I've been taking l-Carnitine Fumarate in the evening and it's giving me serious insomnia. View abstract. The word, "carnitine" comes from the Latin word "carnus," meaning meat, because it was first isolated from meat in 1905. Curr Opin Clin Nutr Metab Care 2000;3:417-24. J Child Neurol 1998;13:546-9. Williams, S. F., Alvarez, J. R., Pedro, H. F., and Apuzzio, J. J. Glutaric aciduria type II and narcolepsy in pregnancy. View abstract. Hoffman, J. R., Ratamess, N. A., Gonzalez, A., Beller, N. A., Hoffman, M. W., Olson, M., Purpura, M., and Jager, R. The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. Sports Med 1996;22:109-32. View abstract. View abstract. Ann.Clin Lab Sci 2009;39(4):399-404. Acetyl-L-Carnitine - WebMD Eur.Rev.Med.Pharmacol Sci 2010;14(4):292-301. Spiekerkoetter, U., Bastin, J., Gillingham, M., Morris, A., Wijburg, F., and Wilcken, B. L-Carnosine and Autism | Nutrition Review Ann.Pharmacother. Am J Nephrol 1990;10(2):109-114. Singh RB, Niaz MA, Agarwal P, et al. Effective dosing of L-carnitine in the secondary prevention of View abstract. Bellinghieri, G., Savica, V., Barbera, C. M., Ricciardi, B., Egitto, M., Torre, F., Valentini, G., D'Iddio, S., Bagiella, E., Mallamace, A., and . Goldenberg, N. A., Krantz, M. J., and Hiatt, W. R. L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. Gesuete, V., Ragni, L., and Picchio, F. M. [The "big heart" of carnitine]. Carnitor (levocarnitine)." . JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. View abstract. View abstract. Does L-carnitine reduce belly fat? View abstract. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. Am J Cardiol. View abstract. 1993;15(1):1-12. Jpn Heart J 1982;23(3):349-359. J Psychiatr.Pract. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. View abstract. Nephron 38 (1984): 120-4, 6. Rodriguez DR, endible A, Gomez N, and et al. Bradycardia Causes + 9 Natural Ways to Improve Slow Heart Rate 2005;16(1):17-22. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. Ann Neurol 1994;36:680-1. Common side effects of L-Carnitine may include: stomach pain; nausea, vomiting; or diarrhea. Lancet 10-11-1980;2(8198):763-764. 2006;12(6):704-714. Melegh, B., Kerner, J., Sandor, A., Vinceller, M., and Kispal, G. Effects of oral L-carnitine supplementation in low-birth-weight premature infants maintained on human milk. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. View abstract. Nikolaos, S., George, A., Telemachos, T., Maria, S., Yannis, M., and Konstantinos, M. Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients. Biogerontology. Reprod.Biomed.Online. Cherchi A, Lai C, Angelino F, et al. Propionyl-L-carnitine is likely to be safe when used under medical supervision. View abstract. Am.J Clin Oncol. Clinical evaluation of the effects of levocarnitine chloride (LC-80) on excercise tolerance in stable angina pectoris by the serial multistage treadmill exercise testing: a multicenter, double-blind study. Int J Sports Med 1989;10(3):169-174. 2010;68(5):743-752. Plioplys AV, Kasnicka I. L-carnitine as a treatment for Rett syndrome. A randomized, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. A. Additional L-carnitine Reduced the Risk of Hospitalization in Patients with Overt Hepatic Encephalopathy on Rifaximin. Int.J Cardiol. View abstract. A., Ghaith, O., Medhat, T., George, S. K., and Elshafey, E. M. Is there a role for oral L-carnitine therapy in anemia and cardiac dysfunction management in Egyptian patients on maintenance hemodialysis? View abstract. Clin J Pain 2008;24(8):731-733. Lacour, B., Di Giulio, S., Chanard, J., Ciancioni, C., Haguet, M., Lebkiri, B., Basile, C., Drueke, T., Assan, R., and Funck-Brentano, J. L. Carnitine improves lipid anomalies in haemodialysis patients. View abstract. Socha, P., Horvath, A., Vajro, P., Dziechciarz, P., Dhawan, A., and Szajewska, H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. Dragan, I. G., Vasiliu, A., Georgescu, E., and Eremia, N. Studies concerning chronic and acute effects of L-carnitina in elite athletes. Jones MG, Goodwin CS, Amjad S, Chalmers RA. Krahenbuhl S. Carnitine metabolism in chronic liver disease. 1999;2(2):65-73. l-Carnitine causes insomnia : r/Supplements - reddit J Huazhong.Univ Sci Technolog.Med.Sci 2006;26(2):188-191. 2011;17(7):H55-H59. Am J Clin Nutr 1989;49(2):283-289. High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. Sheida A, Davar R, Tabibnejad N, Eftekhar M. The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial. Weigel, C., Kiener, C., Meier, N., Schmid, P., Rauh, M., Rascher, W., and Knerr, I. Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. View abstract. Rossignol, D. A. and Frye, R. E. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. View abstract. View abstract. J Trop.Pediatr. Agarwal A, Sengupta P, Durairajanayagam D. Role of L-carnitine in female infertility. Iran J Kidney Dis 2011;5(2):114-118. Drugs Exp Clin Res 1999;25:29-36. Kidney Int 1990;38(5):904-911. Pediatr.Res. Hepatol. Sigma-Tau Pharmaceuticals (2001): 2. 2017;96(39):e8117 View abstract. View abstract. Multicenter trial of L-carnitine in maintenance hemodialysis patients. 7-14-2009;89(26):1858-1861. Clin Exp.Immunol. View abstract. View abstract. View abstract. Long-term l-carnitine treatment of chronic anaemia of patients with end-stage renal failure. L-carnitine seems to decrease how well thyroid hormone works in the body. View abstract. View abstract. G.Ital.Cardiol. Don't use CoQ10 if you're pregnant or breast-feeding without your doctor's approval. 2009;19(73):43-50. 2002;2(3):240-243. Kumar, A., Singh, R. B., Saxena, M., Niaz, M. A., Josh, S. R., Chattopadhyay, P., Mechirova, V., Pella, D., and Fedacko, J. Select a condition to view a list of vitamins. Cell Death.Dis 2010;1:e62. Proc Assoc Am Physicians 1997;109:146-53. Ann Neurol 1988;24:301. New study links L-carnitine in red meat to heart disease Cucinotta D, Passeri M, Ventura S, and et al. Medically reviewed by Drugs.com. Haghighatdoost F, Jabbari M, Hariri M. The effect of L-carnitine on inflammatory mediators: a systematic review and meta-analysis of randomized clinical trials. View abstract. L-carnitine is an amino acid derivative that transports fatty acids into your cells to be processed for energy. View abstract. View abstract. View abstract. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Anzaldi, M. Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease. View abstract. Graziano F, Renato B, Catalano V, and et al. Zilleruelo, G., Novak, M., Hsia, S. L., Goldberg, R., Abitbol, C., Monkus, E., and Strauss, J. BMC.Neurol. Murakami K, Sugimoto T, Woo M, et al. 2010;34(3):295-299. Clin Eur 1983;22:405-415. View abstract. Clin Physiol 1984;4(4):363-365. Mantero MA, Barbero M, Giannini R, and et al. Wang, J. and Wang, X. View abstract. J Pharmacol Exp Ther 1999;290:1482-92. Japanese J.Physical Fitness Sports Med. L-carnitine may aid weight loss. Wei G, Zhou Z, Cui Y, et al. L-Carnitine in maintenance hemo- dialysis clinical, lipid and biochemical effects. 2007;86(1):31-34. View abstract. Sano M, Bell K, Cote L, et al. View abstract. View abstract. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. View abstract. Other drugs may interact with levocarnitine, including prescription and over-the-counter medicines, vitamins, and herbal products. View abstract. Thomas, S., Fischer, F. P., Mettang, T., Pauli-Magnus, C., Weber, J., and Kuhlmann, U. Scarpini E, Sacilotto G, Baron P, et al. View abstract. Drug intervention program in dyslipemic children: use of L-carnitine. Applies to levocarnitine: capsule, capsule liquid filled, solution, tablet. 2008;23(7):1602-1606. View abstract. Clinical and biochemical effects. As stated previously, foods high in sugar and saturated fat have been associated with poor sleep quality and sleep disturbances . View abstract. View abstract. View abstract. Cochrane.Database.Syst.Rev. Efficacy of L-carnitine and propranolol in the management of acute theophylline toxicity. The effect of L-carnitine supplementation on plasma carnitine levels and various performance parameters of male marathon athletes. 11. Drugs Exptl Clin Res 1992;18(1):29-36. View abstract. View abstract. View abstract. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. 12-3-1999;87(4):366-368. BMC Comp Altern Med 2002;2:5. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Fenkci, S. M., Fenkci, V., Oztekin, O., Rota, S., and Karagenc, N. Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. View abstract. 2010;7:35. 2014 Oct;84(4):821-5. 2010;(2):CD007280. View abstract. Support Care Cancer. Weng Y, Zhang S, Huang W, Xie X, Ma Z, Fan Q. Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials. One interesting observation is that ingestion of CoQ10 late in the evening might cause insomnia 15 and this may be due to increased energy levels. Reported side effects are unusual, but include insomnia, headache, diarrhea, low or high blood pressure, nausea, blurred vision, and chest pains. J Ren Nutr 2021;S1051-2276(21)00091-1. View abstract. Bonavita E, Bertuzzi D, Bonavita J, and et al. Sato S, Namisaki T, Furukawa M, et al. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet.